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The majority of LOMS patients (83 %) had a primary progressive disease course, whereas 94 % of the YOMS group had a relapsing-remitting course. Sensory symptoms, ataxia, oculomotor symptoms, cognitive disorder, or fatigue did not differ between both groups. Visual symptoms, residual signs of optic neuritis, and dysarthria were less frequent for LOMS. Motor symptoms were significantly more often present in the LOMS than in patients with YOMS (90 % vs. Mean age at the time of diagnosis was 57 years in the LOMS group - the oldest patient was 82 - and 29 years in the YOMS group. Data pertaining to clinical characteristics, CSF analysis, and cerebral and spinal MRI were compared with those of 52 young-onset MS (YOMS) patients matched for sex and disease duration. Fifty-two patients with definitive multiple sclerosis (MS) diagnosed after the age of 50 years were identified between 19.
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However, this indicates that the immune response to EBV may lead to MS, rather than the EBV infection itself.
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A previous infection with EBV may significantly increase a person’s risk of developing MS. Some evidence links viruses - particularly the Epstein-Barr virus (EBV), which causes infectious mononucleosis - to the development of MS. The National Multiple Sclerosis Society notes that those who smoke are more likely not only to develop MS but also to have a more aggressive disease course. This reduced risk may be due to how vitamin D helps regulate the immune system. Some research suggests that people who spend more time in the sun and those with higher levels of vitamin D are less likely to develop MS. Some of these genes are associated with functions of the immune system and are similar to those that may cause other autoimmune conditions. Research suggests that many genes and gene variations may combine to create vulnerability to MS. According to the National Institute of Neurological Disorders and Stroke, possible causes include: GeneticsĪlthough MS is not a hereditary condition, people may inherit a susceptibility to developing it. Experts do not fully understand what causes MS, but they believe that various factors trigger the immune system to attack the myelin sheath. LOMS and regular onset MS likely share the same causes.
#Loms symptoms how to
We also discuss how to live with the condition. In this article, we look at the symptoms, causes, diagnosis, and treatment of late onset MS. Diagnosing older adults with MS can be challenging because people may mistake their symptoms for the typical signs of aging. However, the condition can present outside of this age bracket. Most people with MS get a diagnosis between the ages of 20 and 40 years. As a result, the body can no longer carry out certain functions. This attack causes scarring, or sclerosis, which impairs the smooth flow of electrical impulses from the brain to the target nerve. With MS, the immune system attacks the myelin sheath that surrounds and protects nerve fibers. In people with autoimmune conditions, the immune system mistakenly attacks healthy cells as though they were pathogens. MS is an autoimmune disorder that affects the central nervous system. When MS appears in older adults, doctors may refer to it as late onset multiple sclerosis (LOMS). Although most people with MS are aged 20–40 years when symptoms appear, the condition can sometimes develop in later life. Multiple sclerosis (MS) is a chronic condition that can result in a wide range of symptoms throughout the body.